giant cell glioblastoma -a rare pediatric cerebral neoplasm

giant cell glioblastoma is an extremely rare variant of glioblastoma (who grade iv) which is characterized by a predominance of bizarre, multinucleated giant cells. these tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. in pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. here, we report a case of a 12-year old female patient who presented in outpatient clinic with a short period history of headache and seizures. a ct scan showed a large right sided frontal space occupying lesion with areas of calcification. the patient was operated and subsequent histopathology revealed a high-grade astrocytic tumor with increased  cellularity,  atypical  mitosis,  bizarre  multinucleated  giant  cells  along  with  large  areas  of ischemic  necrosis  and  calcification.  a  diagnosis  of  giant  cell  glioblastoma  (who  grade  iv)  was made. the patient was symptomatically well at 3-month follow-up.